Zoloft studies

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    Zoloft studies


    The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2). Overall, these studies demonstrated ZOLOFT to be superior to placebo on the Hamilton Rating Scale for Depression (HAMD-17) and the Clinical Global Impression Severity (CGI-S) of Illness and Global Improvement (CGI-I) scores. Study MDD-2 was not readily interpretable regarding a dose response relationship for effectiveness. A third study (Study MDD-3) involved adult outpatients meeting the DSM-III criteria for MDD who had responded by the end of an initial 8-week open treatment phase on ZOLOFT 50–200 mg/day. These patients (n=295) were randomized to continuation on double-blind ZOLOFT 50–200 mg/day or placebo for 44 weeks. A statistically significantly lower relapse rate was observed for patients taking ZOLOFT compared to those on placebo: ZOLOFT [n=11 (8%)] and placebo [n=31 (39%)]. Analyses for gender effects on outcome did not suggest any differential responsiveness on the basis of sex. The effectiveness of ZOLOFT in the treatment of OCD was demonstrated in three multicenter placebo-controlled studies of adult (age 18–65) non-depressed outpatients (Studies OCD-1, OCD-2, and OCD-3). Mothers exposed to SSRI’s late in their pregnancy showed significantly higher rates of premature birth, poor neonatal adaptation, significantly lower mean birth weight and length, and Persistent Pulmonary Hypertension of the Newborn (PPHN). 2002-2006 Simon, Gregory (2002), “Outcome of Prenatal Antidepressant Exposure”. 159: 2055-2061; and Oberlander, Tim (2006), “Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression using Population – Based Linked Health Data”. Use of SSRI antidepressants, including Zoloft, during pregnancy caused lower gestational age and birth weight, longer hospital stays and significantly lower APGAR scores than in non-exposed infants in control groups. 2005-2006 Chambers, Christina (2006), “Selective Serotonin Re-uptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn”. SSRI use, including Zoloft, after the 20th week of pregnancy was significantly associated with PPHN. 2007 Alwan, Sara (2007), “Use of Selective Serotonin-Reuptake Inhibitors in Pregnancy and the Risk of Birth Defects”. Early exposure to SSRIs, including Zoloft, while pregnant showed significant association with anencephaly (an absence of a large part of the brain or skull), craniosynostosis (closed or fused bones on infant’s skull), and omphalocele (an abdominal wall defect in which the intestines and liver remain outside the abdomen in a sac because of a defect in the development of the muscles in the abdominal wall). Luick, Caroi (2007), “First-Trimester Use of Selective Serotonin Re-uptake Inhibitors and the Risk of Birth Defects”. Use of SSRI antidepressant medications, including Zoloft, during pregnancy doubled the risk of babies being born with septal heart defects (ASD and VSD). 2009 Pederson, Lars (2009), “Selective Serotonin Re-uptake Inhibitors in Pregnancy and Congenital Malformation: Population Based Cohort Study”. These same heart defect results were further confirmed in 2009 with the publishing of the Pederson Study.

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    Read user comments about the side effects, benefits, and effectiveness of Zoloft oral. This brought a lot onto my shoulders but Zoloft definately helped. The drug will not do all the work for you. Overall, these studies demonstrated ZOLOFT to be superior to placebo on the Hamilton Rating Scale for Depression HAMD-17 and the Clinical Global Impression Severity CGI-S. Learn about Zoloft Sertraline Hcl may treat, uses, dosage, side effects, drug interactions, warnings, patient labelingZOLOFT is indicated for the treatment of the following See Clinical Studies

    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 24, 2008 - Cognitive behavioral therapy (CBT) and Zoloft are effective treatments for childhood anxiety disorders -- but the combination works best, a government-funded study shows. Anxiety disorders and social phobias limit the lives of at least one in 10 children. Yet up to half of these kids aren't helped by short-term treatment with psychotherapy alone or medications alone. Walkup, MD, and colleagues led a multi-institution, government-funded study to see whether combination treatment would help. The researchers enrolled 488 children and teens age 7 to 17 years. All suffered separation anxiety disorder, generalized anxiety disorder, or social phobia. There were four different treatment groups: Walkup and colleagues conclude that all three of the active treatments -- CBT, Zoloft, or the combination -- are effective short-term treatments for kids with anxiety disorders. : British Journal of Clinical Pharmacology published a study where the authors reviewed 1,216 women with pregnancy-induced hypertension (high blood pressure) and no history of hypertension. A study published in the British Medical Journal looked at 1.6 million infants born between 1996-2007 in Nordic Countries: Denmark, Finland, Iceland, Sweden, Norway. Rynn, MD; and Karl Rickels, MD, “Short-Term Dynamic Psychotherapy Versus Pharmacotherapy for Major Depressive Disorder: A Randomized, Placebo-Controlled Trial,” Journal of Clinical Psychiatry, 73(1):66-67, December 2011. They found that women using antidepressants (including Zoloft) during pregnancy were at increased risk of pregnancy-induced hypertension, especially those on SSRIs. The authors found that mothers who used SSRIs (newer antidepressants, such as Zoloft) late in pregnancy increased the risk of their child being born with a birth defect effecting breathing, know as persistent pulmonary hypertension. Source: Helle Kieler, Miia Artama, Anders Engeland, Orjan Ericsson, Kari Furu, Mika Gissler, Rikke Beck Nielsen, Mette Norgaard, Olof Stephansson, Unnur Valdimarsdottir, Helga Zoega, Bengt Haglund, “Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries,” British Medical Journal, Vol. : The Journal of Clinical Psychiatry published a study where researchers conducted a trial from Nov 2001 to June 2007, with 156 patients who were treated for 16 weeks with either psychotherapy, sertraline (Zoloft) (and if that failed, they were switched to venlafaxine), or a placebo. The British Medical Journal published a study where the authors assessed the risk of several side effects of antidepressants (such a Zoloft) in the elderly, and how these risks are affected by length of use and dosage. Source: Mary A De Vera Ph, Anick Berard Ph D, FISPE, “Antidepressant Use During Pregnancy and the Risk of Pregnancy Induced Hypertension,” British Journal of Clinical Pharmacology, March 21, 2012. The authors concluded that this trial showed that both active treatments failed to be better than placebo. They took data from over 54,000 UK patients who have received at least one prescription of an antidepressant. The British Journal of Psychiatry published a study that looked at daily drug use and daily falls recorded in 248 nursing home residents with dementia from 2006 until 2008. They found that, “All classes of antidepressant drug were associated with significantly increased risks of mortality, attempted suicide/self harm, falls, fractures, and upper gastrointestinal bleeding compared with when these drugs were not being used.” And surprisingly, SSRIs, compared to older antidepressants, had higher rates of many of the previously mentioned risks. Even at low doses, SSRIs (newer antidepressants, such as Zoloft) were associated with increased risk of an injurious fall in nursing home residents with dementia and the use of an SSRI in combination with a hypnotic or sedative further increased the risk. Source: Carol Coupland, Paula Dhiman, Richard Morriss, Antony Arthur, Garry Barton, Julia Hippisley-Cox, “Antidepressant use and risk of adverse outcomes in older people: population based cohort study,” British Medical Journal, Vol. : The Lancet published a study where the authors took the two most commonly prescirbed drugs for depression, sertraline (Zoloft) and mirtazapine (Remeron), and compared it with a placebo. van der Cammen MD, Ph D, “Dose-response relationship between Selective Serotonin Reuptake Inhibitors and Injurious Falls: A study in Nursing Home Residents with Dementia,” British Journal of Clinical Pharmacology, January 18, 2012. In treating depression in dementia patients for 39 weeks, the authors did not find any benefit of using these drugs over placebo, and recommend use of these antidepressants be reconsidered.

    Zoloft studies

    Zoloft - SSRI Uses, Interactions & Common Side Effects, ZOLOFT® sertraline HCl Clinical Studies Pfizer Medical

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  4. SSRIs are generally considered an option during pregnancy, including citalopram Celexa, fluoxetine Prozac and sertraline Zoloft. Potential complications include an increased risk of heavy bleeding after giving birth postpartum hemorrhage, premature birth and low birth weight. Most studies show that SSRIs aren't associated with birth.

    • Antidepressants Safe during pregnancy? - Mayo Clinic.
    • Zoloft Sertraline Hcl Side Effects, Interactions, Warning,.
    • Sertraline Zoloft NAMI National Alliance on Mental Illness.

    Zoloft Side Effects, drug regulatory warnings, studies and adverse reactions reported to the FDA on the antidepressant Zoloft Will Antidepressants Zap Your Good Emotions. these patients might not have the full response,” Combs says. Though there are many case studies, the lack of large clinical studies makes it. Child Anxiety Therapy Plus Zoloft Best. Study Shows Cognitive Behavioral Therapy, Zoloft Work for Child Anxiety -- But Combo Is Best. By Daniel J. DeNoon. From the WebMD Archives.

     
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