We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). The dogs were given sildenafil oral suspension 1 mg/kg every 12 hours for 14 days or placebo in a masked fashion. Clinical signs (frequency of regurgitation and weight gain) and oesophagrams (relative oesophageal diameter, ROD) were evaluated in order to assess the efficacy of drug treatment, by examiners who were unaware of the study protocol. In addition, a set of in vitro experiments on isolated samples of canine lower oesophageal sphincter (LOS) was performed, and the effects of increasing concentrations of sildenafil on basal tone and electrically-stimulated motility were assessed. Sildenafil administration significantly reduced the number of regurgitation episodes (0.88±1.40 v 2.65±1.56, P If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s Rights Link service. You will be able to get a quick price and instant permission to reuse the content in many different ways. While current treatments for congestive heart failure (CHF) in dogs vary based on a practitioner’s personal experiences, there are some strong favorites in the field, cardiology specialists say. For the most common form of heart disease, dilated cardiomyopathy — a degenerative mitral valve disease that causes mitral regurgitation — some veterinary cardiologists also routinely use an aldosterone receptor antagonist, such as spironolactone, Rush said. Most veterinary cardiologists use furosemide; an angiotensin-converting enzyme inhibitor like enalapril, benazepril or lisinopril; and pimobendan for management of the most common forms of congestive heart failure, said John Rush, DVM, MS, Dipl. Others, he said, might add in the drug once signs of congestive heart failure, such as cough, rapid or labored breathing and evidence of pulmonary infiltrates on radiographs, become refractory to these three therapies, Rush said. Rush is a professor at the Cummings School of Veterinary Medicine at Tufts University. “Once these drugs are no longer working well, then additional drugs that might get added into the regimen include sildenafil, amlodipine, torsemide or escalation of the doses of the previously prescribed drugs,” he said. Additionally, many cardiologists also recommend exercise restriction, moderation of dietary sodium intake and close attention to caloric intake to combat the weight loss that can attend advanced heart disease, Rush said. ACVECC, a professor of cardiology and ICU critical care at North Carolina State’s College of Veterinary Medicine, also sees the field embracing pimobendan. not yet in heart failure were treated with pimobendan. In Rush’s experience, most veterinary cardiologists view pimobendan as “a mainstay of therapy” for management of diseases like cardiogenic pulmonary edema, pleural effusion or ascites once congestive heart failure is present. She is also encouraged by emerging reports that pimobendan may be helpful in preventing heart failure. The median time to the primary endpoint — the onset of CHF or sudden death – was 718 days compared with 441 for the group of dogs on a placebo, according to the study. “I think some interesting new information, which some general practitioners might not know, is that pimobendan is being studied in dogs prior to heart failure,” Dr. In what’s most commonly known as the Protect Study, published in 2012, 76 Doberman pinschers in the U. One ongoing study, Evaluating Pimobendan In Cardiomegaly — or EPIC — is evaluating the effectiveness of pimobendan in delaying the onset of clinical signs of congestive heart failure in dogs. Cytotec for abortion Valtrex acyclovir This medicine is authorized for use in human patients and is used by vets under the 'prescribing cascade'. The medicine is not authorized by the Veterinary. The latest Tweets from MSU @michiganstateu. The official Twitter account for Michigan State University. #SpartansWill. East Lansing, MI USA Learn about the vasodilation medication Sildenafil for treatment of dogs and cats. Discover more about CVCA and our compassionate veterinary care. Visit us. (WKRN) - Amy Atkinson's dog, Choppy, is doing much better these days after some scary moments last week. "He was feinting about four or five times,” Atkinson said. “He would just drop and lose all control of himself." She rushed Choppy to the vet and found out he had pulmonary hypertension. “He has a problem with a valve, and he's got a murmur." As shocked as she was to hear the diagnosis, she was even more surprised by what came next. "The doctor came in and she said, 'you know, I know this sounds odd," Atkinson said. "We are giving dogs Viagra these days." Viagra--the pill most known for male enhancement. "It just sounds weird, give your dog Viagra," Atkinson said. John Sessions, an internal medicine specialist for Nashville Veterinary Specialists, gets all kinds of reactions when he brings it up. "It raises some chuckles when we prescribe it," he said. Lakeview Pharmacy now offers Sildenafil for your furry friends at a fraction of the cost of the leading brands such as Revatio. If your dog has heart and lung issues and needs a custom dose or has problems taking medications, we can compound any dose into a tasty dog treat at a low cost. Sildenafil’s effect on the pulmonary vasculature makes the drug useful in treating dogs. In dogs, the drug is most often prescribed to treat heart and lung problems, including pulmonary hypertension resulting from heart failure, pulmonary abnormalities, and cardiac abnormalities. Sildenafil relaxes the lungs, which allows blood to flow more readily, and decreases stress on the heart. Some dogs have experienced flushed or red skin and digestive distress while under treatment with Sildenafil. In the event of accidental overdose, contact your veterinarian immediately. Sildenafil veterinary Sildenafil Exposure in a Dog Today's Veterinary Nurse, MSU @michiganstateu Twitter Buy generic inderal online Aug 2, 2011. You're worried your dog is sick, so you take him to your veterinarian. After a thorough checkup, the doctor tells you that Viagra may be the. Viagra, Botox, and More Yes, Vets Use People Meds on Pets - Vetstreet. Sildenafil CVCA Cardiac Care for Pets. Index to Drug-Specific Information. Sildenafil SF is a phosphodiesterase PDE V inhibitor that causes. for diagnosing PH in veterinary patients as it is readily available and. Mitral Valve Disease and the Cavalier King Charles Spaniel Page 3 -- Veterinary Resources. Mitral Valve Disease Main Page; Research News -- Page 2 Dvm360 Magazine Veterinary Medicine. prognosis—in part, because of advanced diagnostic tools and the availability of sildenafil therapy.