Azithromycin for asthma

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    Azithromycin for asthma


    Condition(s) targeted: Asthma Intervention: Zithromax (Drug); Placebo (Drug) Phase: Phase 4 Status: Completed Sponsored by: Imperial College London Official(s) and/or principal investigator(s): Sebastian L Johnston, MBBS, Ph D, FRCP, Study Chair, Affiliation: Imperial College London Acute attacks (exacerbations) of asthma are common and cause a great deal of suffering in asthmatic patients. Current treatments for asthma attacks are not completely effective and new and better treatments are needed. Viruses often cause asthma attacks and bacterial lung infections have also been associated with asthma attacks. Current asthma guidelines for doctors treating asthma exacerbations do not recommend the routine use of antibiotics. The investigators would like to investigate whether or not azithromycin, which is a safe and well tolerated antibiotic (an antibacterial) that has been used for many years in the treatment of respiratory disease, might be of benefit in asthma attacks. As there is some evidence that azithromycin has anti-viral properties this may add to its benefits (antibiotics don't usually affect viruses). By looking at the effect of azithromycin on asthma attacks this will help us to show whether or not azithromycin should be recommended during an acute asthma attack in addition to the usual care that is provided to these patients as it may help them recover quicker from the exacerbation. The investigators will also be able to look at why azithromycin may be effective - if it is having an anti-bacterial and/or anti-viral effect. BACKGROUND: Macrolides have antimicrobial and anti-inflammatory properties that may be useful in the treatment of chronic asthma. METHODS: We performed a randomized, placebo-controlled, double-blinded effectiveness trial of 12 weekly doses of adjunctive azithromycin, with follow-up to 1 year after randomization, in adults with persistent asthma. Measurements included overall asthma symptoms, asthma quality of life (AQL), and asthma control. Eligible subjects who declined to participate in randomization were offered enrollment into a parallel open-label (OL) azithromycin treatment arm. RESULTS: Of 304 adult asthma patients screened, 97 (32%) were enrolled: 38 were randomized to azithromycin, 37 were randomized to placebo, and 22 opted in as OL subjects. OL subjects had higher rates of severe persistent asthma compared with randomized subjects (32% vs 8%, respectively; P = .012). At 1 year, compared with the placebo arm, subjects randomized to azithromycin were more likely to have an AQL score ≥1 unit increase compared with baseline, but this difference was not statistically significant (36% vs 21% for placebo; P = .335).

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    Azithromycin for bronchial asthma in adults An effectiveness trial / 65. J Am Bd Fam Med 2012; 2-459.*** This clinical trial called AZMATICS found that azithromycin had significant benefits. Nov 26, 2017. Asthma costs the US health care system roughly 50 billion dollars annually.1 And patients with uncontrolled severe asthma 2 exacerbations. Jul 4, 2017. Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment.

    JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) A and B, Acute and Mini AQLQ mean scores by visits for each treatment arm. C, Kaplan-Meier curves of time to a 50% reduction in symptom diary score for each treatment arm (truncated at 10 days).e Methodse Resultse Figures 1-2. Observed mean symptom scores for each day by treatment group and their standard deviatione Table 2. Detailed statistics of observed diary scorese Table 3. Estimated difference in change of diary scores from baseline and 95% confidence intervals for azithromycin compared to the placeboe Figure 3. Observed mean (SD) pulmonary function test results by visit and treatment arme Table 12. Boxplot of residuals for linear and quadratic modelse Table 4. Estimates of pulmonary function mean differencese Tables 13-15. Estimated Day 10 difference in change of diary scores from baseline for subgroupse Figures 6-8. Observed mean diary scores and standard errors of subgroups by treatment arme Table 16. Number of adverse events by SOC category and treatment arme Table 17. Обычная практика: 1 таблетка в дозе 500 мг х 1 раз в день в течение 3 - х дней, иногда до 5 дней. Этот препарат хорошо сочетается с антибиотиками цефалоспоринового ряда: Цефтриаксон по 1 грамму х 1 раз в день - 5 дней внутримышечно или внутривенно капельно или струйно. Саму бронхиальную астму антибиотиками не лечат, применяется "золотой стандарт" в виде ингаляционных кортикостероидов в сочетании с короткодействующими ингаляторами для контроля за течением заболевания, ибо это самый короткий путь к больному органу. Все препараты в виде ингаляторов или через небулайзер. При бронхиальной астме антибиотики назначают, если есть обострение сопутствующего хронического бронхита (ХОБЛ) или пневмонии. Об азитромицине, как антибиотике при лечении бронхолёгочных заболеваний, у, меня лично хорошее мнение. Когда то, мне очень хорошо и быстро помог справиться с трахеобронхитом и тонзиллитом, ещё в 2014 г. У каждого врача, есть круг любимых препаратов, которые когда то помогли самому, при различных заболеваниях. Сдается мне, что, у, вас присутствует обострение хронического бронхита с астматическим компонентом. Элементы бронхиальной астмы имеют инфекционно-аллергическую основу. Не думаю, что азитромицин вызовет, у, вас, что-то аллергическое, но, на всякий случай совместно с ним, следует прикрыться, каким-нибудь антигистаминным средством, тем же диазолином.

    Azithromycin for asthma

    AZithromycin Against pLacebo in Exacerbations of Asthma, Azithromycin to Prevent Asthma Exacerbations What AMAZES Us and.

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  4. The asthma sometimes got somewhat better, but it never was mild again until after the azithromycin treatment. Moreover, the trend over the last few years before taking azithromycin for nine weeks.

    • Severe Asthma "Cure".
    • Effect of azithromycin on asthma exacerbations and. - The Lancet.
    • Azithromycin Can Improve Quality of Life in Asthma Treatment.

    Methods We performed a randomised double-blind placebo-controlled trial in subjects with exacerbation-prone severe asthma. Subjects received low-dose. Азитромицина на этом не исчерпан, и, несомнен-но, будут интересны дальнейшие исследования по установлению практического значения противо-воспалительного, иммуномодулирующего и. Asthma story, Asthma cure research relating asthma to bacteria Chlamydia, asthma Dr Hahn potential cure, AsthmaStory, buy zithromax online 250 mg, buy zithromax online 500 mg.

     
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