Sildenafil mode of action

Discussion in 'Canadian Rx Pharmacy Online' started by go2be, 21-Aug-2019.

  1. DiQ New Member

    Sildenafil mode of action


    VIAGRA (sildenafil citrate) is a c GMP-specific phosphodiesterase type 5 (PDE5) inhibitor, used for the treatment of male erectile dysfunction. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the in response to sexual stimulation. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (c GMP), producing smooth muscle relaxation in the have shown that sildenafil has between 10 and 10,000-fold greater selectivity for PDE5 than for other phosphodiesterase isoforms namely PDEs 1, 2, 3, 4, and 6 and greater than 700-fold effect on PDE7-PDE11. In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the c AMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Sildenafil is about 10-fold as potent for PDE5 compared to PDE6, an isoenzyme found in the retina; this lower selectivity is thought to be the basis for colour vision abnormalities observed with higher doses or plasma levels of sildenafil (see WARNINGS AND PRECAUTIONS, DETAILED PHARMACOLOGY). PDE5 is also found in lower concentrations in platelets, vascular and visceral smooth muscles, and skeletal muscle. The sildenafil-induced inhibition of PDE5 in these tissues appears to be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed (see WARNINGS AND PRECAUTIONS). The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

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    Learn about Viagra Sildenafil Citrate may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and. Mechanism Of Action. Mechanism of Action. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual. The oral meds began with Viagra or sildenafil. This was the first of a group of drugs called phosphodieterase inhibitors or PD5 inhibitors for short. They work b.

    If you said no, then you've definitely heard of Viagra, the brand name for the generic term of sildenafil. Viagra is used to treat erectile dysfunction (impotence). Another brand name version of sildenafil, Revatio, is used to manage pulmonary arterial hypertension (PAH), or high blood pressure (hypertension) in the arteries of the lungs ('pulmon-'). You can check out the structure of sildenafil in this lesson's image. And if you keep reading, you'll also learn exactly how it is that sildenafil works at treating both of these conditions. An erection occurs and disappears as a result of an interplay of forces. Not to be funny, just for simplicity's sake, we'll call the forces that lead to an erection as the good guys and the ones that cause one to disappear as the bad guys. Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

    Sildenafil mode of action

    Sildenafil citrate - mode of action - DoctorNDTV, Viagra - FDA

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  3. Sildenafil C22H30N6O4S CID 135398744 - structure, chemical names, physical. The mechanism of action of sildenafil is as a Phosphodiesterase 5 Inhibitor.

    • Sildenafil C22H30N6O4S - PubChem.
    • Sildenafil mechanism of action - MedHelp.
    • Viagra sildenafil citrate dose, indications, adverse effects..

    Sildenafil citrate mechanism of action Effects of viagra 50 mg bonus free pills Sildenafil Mode Of Action the Best Customer Services And Advantage Of Best Prices, Discreet Fastest Worldwide Shipping. Where to buy without a doctor's prescription? Mode of Action. Filling the penis with blood occurs by delivering blood through blood vessels, which leads to an increase in the size of penis and itsIt should be remembered that sildenafil citrate must not be used simultaneously with grapefruit, as this leads to an overdose of the main substance.

     
  4. DRONkins New Member

    With any substance you put in your body, whether it’s an illicit drug, a prescription, or an herbal supplement, there may be possible side effects and also interactions and dangers of mixing it with other substances. It’s important that you always speak with your doctor about the interactions and dangers of mixing substances you may be taking, and you should be forthcoming with your physician so that they can make the right decision for you. These are two substances that are frequently used, and sometimes abused, so what are the possible interactions and dangers of mixing the two? Below is more information about Xanax as well as weed, and the interactions and dangers of mixing these two substances. Before exploring the interactions and dangers of mixing Xanax and weed, what is Xanax? Xanax is the brand name of the generic alprazolam, and it’s prescribed to treat anxiety and panic disorders most often, although it may also be used for other reasons such as to treat the symptoms of seizure disorders. It’s classified as a benzodiazepine, and when someone takes Xanax, it slows down certain activity in their brain, which allows them to feel calmer and more relaxed. Some of the side effects of this prescription medication can include dizziness, drowsiness, and confusion. Getting High on Xanax How Much Do You Need? What happens to your brain when you take Xanax - Business Insider Why Xanax is the Most Popular Anti-Anxiety Drug in America.
     
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    Is Clonidine Dangerous? Can it Be Abused? - Oxford Treatment Center The Addictive Potential of Clonidine. Clonidine is not considered to be a major drug of abuse; however, it does have the potential to be abused. For some.

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