Answer: Both Warfarin (brand name - and Plavix (generic - clopidogrel bisulfate) are considered blood thinners, but they are very different drugs with different actions. Warfarin works by counteracting Vitamin K in the plasma of the blood. Vitamin K is key in the coagulation pathways responsible for the clotting of blood, and with less activity of Vitamin K blood takes longer to clot. Too little, as well as too much warfarin can be dangerous. If taking a dose that is ineffective, clot formation is not adequately prevented and the problem you are trying to treat or prevent may very well occur. Taking too much warfarin raises the risk of bleeding, especially in the gastrointestinal tract and, in the elderly, the brain. People taking this drug must have their blood monitored to measure the time it takes to clot, which can result in frequent adjustments of their dose. Plasma warfarin concentrations and warfarin effects may be increased. Com, Lasix (furosemide) may displace warfarin from plasma protein binding sites. This interaction is characterized as minor clinical importance. However, everything else being the same, and that she did not confuse her Lasix (furosemide) with Coumadin and take more Coumadin than thought, then this interaction may have contributed to the increased inr. In any case, this is too high and if she is bleeding, or altered mental status or paralysis, she should be sent to the hospital for evaluation and treatment. However if she is stable, hold the Coumadin and retest her inr. She can resume taking her dose when the inr is less than 5.0. What is nolvadex Buy propecia lloyds A Minor Drug Interaction exists between Coumadin and Lasix. View detailed information regarding this drug interaction. Anticoagulants warfarin-Coumadin. Coumadin- increase serum concentration- increased effect of. Furosemide-diuretic can increase streptomycin blood. In a study of 11 normal subjects who received either furosemide or bumetanide, response to warfarin was unaffected by either diuretic. The mean prothrombin. HCTZ (hydrochlorothiazide) is a very weak diuretic that is very good for Hypertension and sometimes, the first drug used. Lasix (furosemide) is a stronger diuretic better used for congestive heart failure than for hypertension. Read more Furosemide is a potent diuretic which increases dramatically urine output in most patients. It is most frequently used in patients who are fluid overloaded such as in congestive heart failure. Potassium , sodium and magnesium can be lost in excess with the use of Furosemide and must be closely monitored. It is much stronger than other diuretics used for Coumadin (warfarin) is an anticoagulant that works to block production of some of the building blocks used in blod clotting. It needs to be monitored regularly due to the fact that the levels can very in the body, affected by foods you eat, interactions with other medications, and your own metabolism. Read more See 3 more doctor answers Good hydration status and less alcohol (which is dehydrating) lead to more favorable outcome profiles in those with portal vein thrombosis. Alcohol may also raise your risk of bleeding in the setting of coumadin (warfarin). Read more See 1 more doctor answer cozaar (losartan) or an ACE inhibitor is better for diabetes. I mentioned in an earlier Small Talk thread that Jerry's feet, ankles & legs had been swelling and he started on 1 or 2 Lasix a day. Lasix and coumadin Practical tips for warfarin dosing and monitoring, Significant Drug Interactions with Tuberculosis Medications Xenical constipationCiprofloxacin 1000mg Ther Drug Monit. 1997 Jun;193361-3. Decreased hypoprothrombinemic effect of warfarin associated with furosemide. Laizure SC1, Madlock L, Cyr M, Self T. Decreased hypoprothrombinemic effect of warfarin associated with.. The effect of furosemide and bumetanide on warfarin metabolism and.. Digoxin and Coumadin - Patient Medications - allnurses. That said, if your husband lost a lot of Fluid because of the Lasix / Furosemide, that *might* cause the concentration of Coumadin / Warfarin to rise in his blood. That might be a good Question for you /him to ask his Coumadin Clinic or PCP. 'AL Capshaw' COUMADIN crystalline warfarin sodium is an anticoagulant which acts by. COUMADIN for Injection is supplied as a sterile, lyophilized powder, which, after. The authors describe a case of furosemide possibly inhibiting the hypoprothrombinemic effect of warfarin. The initiation of furosemide dosing in a patient receiving a stable dose of warfarin was.