Dexamethasone to prednisone

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  1. ArchangelNN Guest

    Dexamethasone to prednisone


    Conventional therapy for childhood acute lymphoblastic leukemia (ALL) includes prednisone and oral 6-mercaptopurine. Prior observations suggested potential advantages for dexamethasone over prednisone and for intravenous (IV) over oral 6-mercaptopurine, which remain to be validated. We report the results of a randomized trial of more than 1000 subjects that examined the efficacy of dexamethasone and IV 6-mercaptopurine. Children with National Cancer Institute standard-risk ALL were randomly assigned in a 2 × 2 factorial design to receive dexamethasone (6 mg/m/d). The second randomized assignment was for daily oral or weekly IV 6-mercaptopurine during consolidation. During maintenance, 5 days of the randomized steroid was given monthly, at the same dose, and all patients received daily oral 6-mercaptopurine. During delayed intensification, all patients received a dexamethasone dosage of 10 mg/m/d for 21 days, with taper. The NICE British National Formulary (BNF) and British National Formulary for Children (BNFc) sites are only available to users in the UK, Crown Dependencies and British Overseas Territories. If you believe you are seeing this page in error please contact us.

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    Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia a. Dexamethasone long-acting. 8 mg. Methylprednisolone intermediate-acting. 8 mg. Triamcinolone intermediate-acting. 10 mg. Prednisone.

    Fludrocortisone (Florinef) is used for its mineralocorticoid activity (causing increased reabsorption of sodium and loss of potassium/hydrogen). Although fludrocortisone technically possesses a small degree of anti-inflammatory activity (1/10th that of hydrocortisone), this effect is negibile at normal therapeutic doses of fludrocortisone (such as 0.05 to 0.2 mg per day). For this reason, fludrocortisone cannot realistically be converted to another corticosteroid on the basis of anti-inflammatory potency. Corticosteroids play a significant role in the treatment of acute lymphoblastic leukemia (ALL) in children. A common first line medication for acute lymphoblastic leukemia is dexamethasone because of the drug’s high potency and high anti-leukemic effects. However, due to Dexamethasone’s high potency, the drug can also produce neuropsychological side effects which could affect children’s’ cognitive development. Neuropsychological side effects can include changes in mood, decrease cognition, changes in behavior, and sleep disorders.“Steroid-induced neuropsychological side effects are important negative determinants of the quality of life of children during cancer treatment.” Replacing Dexamethasone with a less potent corticosteroid, such as prednisone, could lessen the side effects children experience. The purpose of this review was to compare the neuropsychological side effects between dexamethasone and prednisone in children treated for acute lymphoblastic leukemia. Determining if a clinically significant difference exist between dexamethasone and prednisone, could provide a more viable option with lower neuropsychological side effects for children.“The review included English-language studies of children, determined through a systematic search in the database of MEDLINE (1960 till December 2013), EMBASE (1960 till December 2013), and The Cochrane Library (till December 2013).”Articles were selected on the basis of title and abstract by two independent reviewers (LTW and MAHH) using the following inclusion criteria. Children with leukemia/ALL that were receiving dexamethasone and/or prednisone.

    Dexamethasone to prednisone

    Dexamethasone vs Prednisone Comparison -, Dexamethasone versus prednisone and daily oral versus weekly.

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  6. Prednisone and dexamethasone are synthetic man-made corticosteroids steroids used for suppressing the immune system and inflammation. These drugs have effects similar to other corticosteroids such as triamcinolone Kenacort, methylprednisolone, and prednisolone Prelone.

    • Prednisone vs. dexamethasone Side Effects, Symptoms..
    • Corticosteroid Dose Equivalents - Medscape eMedicine.
    • Lenalidomide, Bortezomib, and Dexamethasone with..

    Dexamethasone Tablets USP are available for oral administration containing either 0.5 mg, 0.75 mg, 1 mg, 1.5 mg, 2 mg, 4 mg or 6 mg of Dexamethasone USP. Dexamethasone is a corticosteroid that prevents the release of substances in the body that cause inflammation. Dexamethasone is used to treat many different inflammatory conditions such as allergic disorders and skin conditions. The steroid conversion calculator can be utilized for drugs administered orally or by IV and the following. prednisone and dexamethasone on human pituitary.

     
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  8. wolf-wolf Well-Known Member

    Prednisone and prednisolone are glucocorticoids which reduce inflammation and inhibit immune system responses. They are several times stronger than the stress hormone “cortisol” which is produced naturally in a dog’s adrenal glands and are often used for treating Addison’s disease in which your dog’s glands do not produce enough cortisol on their own. Because they suppress the immune system they are also effective in the treatment of allergies and are sometimes used as a follow-up to epinephrine when dogs have suffered anphylactic shock (a very severe allergic reaction). In terms of antiinflammatory effects, prednisolone is 4x more potent than hydrocortisone. It is not to be confused with methylprednisolone, which is a slightly more powerful variant of the drug. What’s the difference between prednisone and prednisolone? Prednisone is actually a “precursor” to prednisolone. Prednisolone Rx - Medscape Drugs & Diseases Prednisolone - Uses, Dosage, Side Effects, Composition & more Practo Prednisone vs. Prednisolone Side Effects, Dosage & Uses
     
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