Valacyclovir is used to treat infections caused by certain types of viruses. In children, it is used to treat cold sores around the mouth (caused by herpes simplex) and chickenpox (caused by varicella zoster). In adults, it is used to treat shingles (caused by herpes zoster) and cold sores around the mouth. The viruses that cause these infections continue to live in the body even between outbreaks. Valacyclovir is also used to treat outbreaks of genital herpes. Valacyclovir decreases the severity and length of these outbreaks. In people with frequent outbreaks, this medication is used to reduce the number of future episodes. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. Read the Patient Information Leaflet if available from your pharmacist before you start taking valacyclovir and each time you get a refill. 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Medscape - Herpes simplex, zoster-specific dosing for Valtrex valacyclovir, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Valaciclovir (Brand names: Zelitrex, Valtrex, among others) belongs to a group of medicines called antivirals. It works by killing or stopping the growth of viruses called herpes simplex (HSV), varicella zoster (VZV) and cytomegalovirus (CMV). Valaciclovir can be used to treat shingles, herpes simplex infections of the skin and genital herpes. It is also used to help prevent these infections from returning. Valaciclovir can be used also to treat cold sores, to prevent infection with cytomegalovirus after organ transplants and treat and prevent herpes simplex virus infections of the eye. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability than aciclovir. 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